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cochrane meta-analysis a cochrane meta-analysis evaluated trials in which loop diuretics were used to treat hypertension the analysis only found 3 trials where furosemide had been compared to placebo in the treatment of hypertension none were found for bumetanide and torsemide the following results were seen systolic blood pressure sbp in two trials comparing furosemide 40 mg a day to placebo, furosemide lowered sbp by an average of 5.